BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DOCK2
AI662014, AW122239, CED-5, Hch, MBC, RP23-32J15.2
dedicator of cyto-kinesis 2
GO Process (16)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- T cell activation [IMP]
- T cell proliferation [IMP]
- alpha-beta T cell activation [IMP]
- alpha-beta T cell proliferation [IMP]
- chemotaxis [IMP]
- cytoskeleton organization [IDA]
- establishment of T cell polarity [IMP]
- immunological synapse formation [IMP]
- macropinocytosis [IMP]
- membrane raft polarization [IMP]
- myeloid dendritic cell activation involved in immune response [IMP]
- negative thymic T cell selection [IMP]
- positive regulation of Rac GTPase activity [IMP]
- positive regulation of Rac protein signal transduction [IC]
- positive regulation of phagocytosis [IMP]
- positive thymic T cell selection [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID