BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NME1
AL024257, NDPK-A, NM23-M1, NM23A, RP23-378I13.1
NME/NM23 nucleoside diphosphate kinase 1
GO Process (14)
GO Function (14)
GO Component (10)
Gene Ontology Biological Process
- DNA catabolic process [ISO]
- lactation [IMP]
- mammary gland development [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of myeloid leukocyte differentiation [ISO]
- nucleic acid phosphodiester bond hydrolysis [ISO]
- nucleoside diphosphate phosphorylation [IBA, ISO]
- nucleoside triphosphate biosynthetic process [IBA]
- positive regulation of DNA binding [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- purine nucleotide metabolic process [IBA]
- pyrimidine nucleotide metabolic process [IBA]
- regulation of apoptotic process [IBA]
Gene Ontology Molecular Function- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
- ATP binding [ISO]
- GTP binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- deoxyribonuclease activity [ISO]
- enzyme binding [ISO]
- gamma-tubulin binding [ISO]
- identical protein binding [ISO]
- intermediate filament binding [ISO]
- magnesium ion binding [ISO]
- nucleoside diphosphate kinase activity [IBA, ISO]
- poly(A) RNA binding [ISO]
- protein kinase binding [ISO]
- ribosomal small subunit binding [ISO]
- single-stranded DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID