BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CORO1A
Clabp, Lmb3, TACO, p57
coronin, actin binding protein 1A
GO Process (26)
GO Function (8)
GO Component (18)
Gene Ontology Biological Process
- T cell homeostasis [IMP]
- actin cytoskeleton organization [ISO]
- actin filament organization [IMP]
- calcium ion transport [IMP]
- cell migration [IMP]
- cell-substrate adhesion [ISO]
- cellular response to interleukin-4 [IDA]
- early endosome to recycling endosome transport [IMP]
- homeostasis of number of cells within a tissue [IMP]
- leukocyte chemotaxis [IMP]
- negative regulation of actin nucleation [IBA, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of vesicle fusion [IMP]
- nerve growth factor signaling pathway [IGI]
- phagocytosis [ISO]
- phagolysosome assembly [IBA, ISO]
- positive chemotaxis [IBA, ISO]
- positive regulation of T cell activation [IMP]
- positive regulation of T cell proliferation [IMP]
- positive regulation of cell migration [IMP]
- regulation of actin filament polymerization [IMP]
- regulation of actin polymerization or depolymerization [IMP]
- regulation of cell shape [IMP]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- response to cytokine [IMP]
- uropod organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- actin filament [ISO]
- axon [IDA]
- cell [IMP]
- cell leading edge [IDA]
- cell-cell junction [IDA]
- cortical actin cytoskeleton [IBA, ISO]
- cytoplasm [ISO]
- early endosome [IDA]
- extracellular vesicular exosome [ISO]
- immunological synapse [IDA]
- intracellular [IMP]
- lamellipodium [IBA, ISO]
- membrane [ISO]
- phagocytic cup [IBA, ISO]
- phagocytic vesicle [IBA, ISO]
- plasma membrane [IDA, ISO]
- protein complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID