BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ADAR
AV242451, Adar1, Adar1p110, Adar1p150, mZaADAR
adenosine deaminase, RNA-specific
GO Process (23)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- adenosine to inosine editing [IDA, IMP, ISO]
- base conversion or substitution editing [ISO]
- defense response to virus [IMP]
- definitive hemopoiesis [IMP]
- erythrocyte differentiation [IMP]
- hematopoietic progenitor cell differentiation [IMP]
- hematopoietic stem cell homeostasis [IMP]
- in utero embryonic development [IMP]
- miRNA loading onto RISC involved in gene silencing by miRNA [ISO]
- negative regulation of RNA interference [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein kinase activity by regulation of protein phosphorylation [IMP, ISO]
- negative regulation of type I interferon-mediated signaling pathway [IMP]
- negative regulation of viral genome replication [IMP]
- osteoblast differentiation [IMP]
- positive regulation of viral genome replication [IMP, ISO]
- pre-miRNA processing [ISO]
- production of miRNAs involved in gene silencing by miRNA [IMP]
- protein export from nucleus [ISO]
- protein import into nucleus [ISO]
- response to interferon-alpha [ISO]
- response to virus [ISO]
- somatic diversification of immune receptors via somatic mutation [IDA]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID