BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
THY1
CD90, T25, Thy-1, Thy-1.2, Thy1.1, Thy1.2
thymus cell antigen 1, theta
GO Process (14)
GO Function (5)
GO Component (14)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- angiogenesis [IDA]
- cytoskeleton organization [ISO]
- focal adhesion assembly [ISO]
- negative regulation of T cell receptor signaling pathway [IDA]
- negative regulation of axonogenesis [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of protein kinase activity [ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho GTPase activity [ISO]
- positive regulation of T cell activation [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- retinal cone cell development [IMP]
- single organismal cell-cell adhesion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- anchored component of external side of plasma membrane [IDA]
- anchored component of plasma membrane [ISO]
- apical plasma membrane [ISO]
- cell surface [ISO]
- cytosol [ISO]
- dendrite [IDA]
- endoplasmic reticulum [ISO]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- membrane raft [IDA]
- myelin sheath [IDA]
- plasma membrane [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID