BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKCD
AI385711, D14Ertd420e, PKC[d], PKCdelta, Pkcd
protein kinase C, delta
GO Process (35)
GO Function (8)
GO Component (10)
Gene Ontology Biological Process
- B cell proliferation [IMP]
- apoptotic process [ISO]
- aspartate transport [ISO]
- cellular senescence [ISO]
- collagen metabolic process [ISO]
- defense response to bacterium [IMP]
- immunoglobulin mediated immune response [IMP]
- interleukin-10 production [IMP]
- interleukin-12 production [IMP]
- intracellular signal transduction [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [IMP]
- negative regulation of filopodium assembly [IMP]
- negative regulation of glial cell apoptotic process [ISO]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP]
- negative regulation of platelet aggregation [IMP]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic signaling pathway [IDA]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to oxidative stress [ISO]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID