BAIT
FANCD2
2410150O07Rik, AU015151, BB137857, FA-D2, FA4, FACD, FAD, FANCD
Fanconi anemia, complementation group D2
GO Process (4)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EIF2AK2
2310047A08Rik, 4732414G15Rik, AI467567, AI747578, Pkr, Prkr, Tik
eukaryotic translation initiation factor 2-alpha kinase 2
GO Process (24)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- activation of MAPKK activity [ISO]
- endoplasmic reticulum unfolded protein response [IDA]
- negative regulation of apoptotic process [IGI]
- negative regulation of osteoblast proliferation [ISO]
- negative regulation of translation [ISO]
- negative regulation of viral genome replication [IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of NIK/NF-kappaB signaling [IMP]
- positive regulation of apoptotic process [ISO]
- positive regulation of chemokine production [IMP]
- positive regulation of cytokine production [IMP]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of NLRP3 inflammasome complex assembly [IMP]
- regulation of hematopoietic progenitor cell differentiation [IMP]
- regulation of hematopoietic stem cell differentiation [IMP]
- regulation of hematopoietic stem cell proliferation [IMP]
- response to interferon-alpha [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [ISO]
- response to virus [ISO]
- response to vitamin E [ISO]
- translation [IDA]
Gene Ontology Molecular Function
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function.
Fancd2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective in human cancers. The full repertoire of Fancd2 functions in normal development and tumorigenesis remains to be determined. Here we developed a Flag- and hemagglutinin-tagged Fancd2 knock-in mouse strain that allowed a high throughput mass spectrometry approach to search for Fancd2-binding proteins in ... [more]
Sci Rep Apr. 05, 2017; 7();45626 [Pubmed: 28378742]
Throughput
- High Throughput
Curated By
- BioGRID