A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.

Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM

Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous recombination-type double strand break repair (HR-DSBR) through physical interactions with BRCA1, BRCA2, and RAD51. To further understand the mechanisms underlying PALB2-mediated DNA repair and tumor suppression functions, ... [more]

Proc. Natl. Acad. Sci. U.S.A. May. 21, 2013; 110(21);8632-7 [Pubmed: 23657012]

Throughput

Low Throughput

Additional Notes

increased acute chromosomal damage and genome instability

Curated By

BioGRID

Interaction Summary

PALB2

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [ISO]

Gene Ontology Cellular Component

TRP53BP1