BAIT
BRCA2
Fancd1, RAB163
breast cancer 2
GO Process (36)
GO Function (6)
GO Component (8)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IMP]
- DNA recombination [ISO]
- brain development [IMP]
- cell aging [IMP]
- cell proliferation [IMP]
- cellular response to DNA damage stimulus [IDA]
- centrosome duplication [IBA, ISO]
- chordate embryonic development [IMP]
- chromosome organization [IMP]
- cytokinesis [ISO]
- double-strand break repair [IMP, ISO]
- double-strand break repair via homologous recombination [IMP, ISO]
- female gonad development [IMP]
- hemopoiesis [IMP]
- histone H3 acetylation [ISO]
- histone H4 acetylation [ISO]
- homologous chromosome orientation involved in meiotic metaphase I plate congression [ISO]
- inner cell mass cell proliferation [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IGI, IMP]
- male meiosis I [IMP]
- mammary gland development [ISO]
- multicellular organism growth [ISO]
- negative regulation of mammary gland epithelial cell proliferation [ISO]
- nucleotide-excision repair [ISO]
- oocyte maturation [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of cell proliferation [IBA]
- regulation of cytokinesis [IMP]
- regulation of transcription, DNA-templated [IBA]
- replication fork protection [IMP]
- response to UV-C [IMP]
- response to X-ray [IMP]
- response to gamma radiation [IMP]
- spermatogenesis [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TRP53BP1
53BP1, Tp53bp1, m53BP1, p53BP1, RP23-437L13.2
transformation related protein 53 binding protein 1
GO Process (5)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II transcription cofactor activity [ISO]
- damaged DNA binding [IDA]
- methylated histone binding [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- telomeric DNA binding [IDA]
- transcription factor binding [TAS]
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer.
Germ-line mutations in PALB2 lead to a familial predisposition to breast and pancreatic cancer or to Fanconi Anemia subtype N. PALB2 performs its tumor suppressor role, at least in part, by supporting homologous recombination-type double strand break repair (HR-DSBR) through physical interactions with BRCA1, BRCA2, and RAD51. To further understand the mechanisms underlying PALB2-mediated DNA repair and tumor suppression functions, ... [more]
Proc. Natl. Acad. Sci. U.S.A. May. 21, 2013; 110(21);8632-7 [Pubmed: 23657012]
Throughput
- Low Throughput
Curated By
- BioGRID