SYNGAP1
Gene Ontology Biological Process
- Ras protein signal transduction [IDA]
- dendrite development [IMP]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of axonogenesis [IDA]
- negative regulation of neuron apoptotic process [IMP]
- pattern specification process [IMP]
- positive regulation of Rab GTPase activity [IDA]
- positive regulation of Ras GTPase activity [IBA, ISO]
- receptor clustering [IMP]
- regulation of MAPK cascade [IMP]
- regulation of long-term neuronal synaptic plasticity [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of synaptic plasticity [ISO]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHANK1
Gene Ontology Biological Process
- adult behavior [ISO]
- associative learning [IMP]
- dendritic spine morphogenesis [IMP]
- determination of affect [ISO]
- habituation [IMP]
- long-term memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- neuromuscular process controlling balance [IMP]
- olfactory behavior [IMP]
- positive regulation of dendritic spine development [ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- protein complex assembly [ISO]
- protein localization to synapse [IMP]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- righting reflex [IMP]
- social behavior [IMP, ISO]
- synapse maturation [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [IMP, ISO]
- SH3 domain binding [ISO]
- ankyrin repeat binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein complex binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- scaffold protein binding [ISO]
- somatostatin receptor binding [ISO]
- GKAP/Homer scaffold activity [IMP, ISO]
- SH3 domain binding [ISO]
- ankyrin repeat binding [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor binding [IPI, ISO]
- protein C-terminus binding [ISO]
- protein complex binding [ISO]
- receptor signaling complex scaffold activity [ISO]
- scaffold protein binding [ISO]
- somatostatin receptor binding [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISO]
- dendrite [IDA]
- dendritic spine [IDA, ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [IDA]
- membrane [ISO]
- neuron projection [IDA]
- neuronal postsynaptic density [IDA]
- plasma membrane [IDA]
- postsynaptic membrane [IDA, ISO]
- synapse [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SYNGAP1 SHANK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
SYNGAP1 SHANK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2333331 | |
SYNGAP1 SHANK1 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 0.5858 | BioGRID | 3500085 |
Curated By
- BioGRID