BAIT
TNIK
1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik
TRAF2 and NCK interacting kinase
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of JNKK activity [ISO]
- cytoskeleton organization [ISO]
- intracellular signal transduction [IBA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of dendrite morphogenesis [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PRKACA
PKCD, Pkaca
protein kinase, cAMP dependent, catalytic, alpha
GO Process (20)
GO Function (10)
GO Component (16)
Gene Ontology Biological Process
- cellular response to glucose stimulus [ISO]
- cellular response to parathyroid hormone stimulus [IMP]
- mesoderm formation [IGI]
- negative regulation of meiotic cell cycle [ISO]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IGI]
- neural tube closure [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of protein export from nucleus [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- regulation of cellular respiration [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of proteasomal protein catabolic process [ISO]
- regulation of protein processing [IGI]
- regulation of synaptic transmission [IMP]
- regulation of synaptic transmission, glutamatergic [ISO]
- regulation of tight junction assembly [ISO]
- sperm capacitation [IDA]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- Rab GTPase binding [ISO]
- cAMP-dependent protein kinase activity [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA]
- protein serine/threonine/tyrosine kinase activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- AMP-activated protein kinase complex [ISO]
- Golgi apparatus [ISO]
- cAMP-dependent protein kinase complex [ISO]
- centrosome [ISO]
- ciliary base [IDA]
- cytoplasm [IDA, ISO]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- mitochondrion [IDA]
- neuromuscular junction [IDA]
- neuron projection [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sperm midpiece [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult non-postsynaptic density (PSD)
Curated By
- BioGRID