BAIT
TNIK
1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik
TRAF2 and NCK interacting kinase
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of JNKK activity [ISO]
- cytoskeleton organization [ISO]
- intracellular signal transduction [IBA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of dendrite morphogenesis [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CACNA1A
APCA, BI, Caca1a, Cacnl1a4, Cav2.1, Ccha1a, EA2, FHM, HPCA, MHP, MHP1, SCA6, alpha1A, la, nmf352, rkr, tg
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (50)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- adult walking behavior [IGI, IMP]
- behavioral response to pain [IMP]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IGI]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- calcium ion-dependent exocytosis of neurotransmitter [IMP]
- cell death [ISO]
- cell growth [IMP]
- cellular chloride ion homeostasis [IMP]
- central nervous system neuron differentiation [IMP]
- cerebellar Purkinje cell differentiation [IMP]
- cerebellar Purkinje cell layer development [IMP]
- cerebellar molecular layer development [IMP]
- cerebellum maturation [IMP]
- dendrite morphogenesis [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- glucose metabolic process [IMP]
- hormone metabolic process [IMP]
- membrane depolarization [IMP]
- membrane depolarization during action potential [IBA]
- musculoskeletal movement, spinal reflex action [IMP]
- negative regulation of hormone biosynthetic process [IMP]
- negative regulation of neuron apoptotic process [IMP]
- neurological system process [IMP]
- neuromuscular process [IGI, IMP]
- neuromuscular process controlling balance [IMP]
- neuromuscular synaptic transmission [IMP]
- neuron-neuron synaptic transmission [IMP]
- neurotransmitter metabolic process [IMP]
- positive regulation of cytosolic calcium ion concentration [IDA, ISO]
- receptor clustering [IMP]
- regulation of acetylcholine secretion, neurotransmission [IMP]
- regulation of axonogenesis [IMP]
- regulation of calcium ion-dependent exocytosis [IDA]
- regulation of ion transmembrane transport [IGI]
- regulation of membrane potential [IMP]
- response to pain [IMP]
- rhythmic synaptic transmission [IMP]
- sensory perception of pain [ISO]
- spinal cord motor neuron differentiation [IMP]
- sulfur amino acid metabolic process [IMP]
- synapse assembly [IMP]
- synaptic transmission [IMP, ISO]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thyroid hormone metabolic process [IMP]
- transmission of nerve impulse [IMP]
- vestibular nucleus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID