BAIT
TNIK
1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik
TRAF2 and NCK interacting kinase
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of JNKK activity [ISO]
- cytoskeleton organization [ISO]
- intracellular signal transduction [IBA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of dendrite morphogenesis [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
CACNB4
3110038O15Rik, Cchb4, lh, RP23-435G20.4
calcium channel, voltage-dependent, beta 4 subunit
GO Process (22)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- Peyer's patch development [IMP]
- T cell differentiation [IMP]
- T cell receptor signaling pathway [IMP]
- adult walking behavior [IMP]
- cAMP metabolic process [IMP]
- calcium ion transmembrane transport [IMP, ISO]
- calcium ion transport [IMP, ISO]
- cellular calcium ion homeostasis [IMP]
- detection of light stimulus involved in visual perception [IMP]
- gamma-aminobutyric acid secretion [IMP]
- gamma-aminobutyric acid signaling pathway [IMP]
- muscle fiber development [IMP]
- neurological system process [IMP]
- neuromuscular junction development [IMP]
- neuronal action potential propagation [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of membrane potential [IMP]
- regulation of voltage-gated calcium channel activity [IBA, ISO]
- spleen development [IMP]
- synaptic transmission, GABAergic [IMP]
- synaptic transmission, glutamatergic [IMP]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID