BAIT
TNIK
1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik
TRAF2 and NCK interacting kinase
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of JNKK activity [ISO]
- cytoskeleton organization [ISO]
- intracellular signal transduction [IBA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of dendrite morphogenesis [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
GRM5
6430542K11Rik, AI850523, Glu5R, Gprc1e, mGluR5, mGluR5b
glutamate receptor, metabotropic 5
GO Process (15)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IBA, ISO]
- activation of MAPKKK activity [ISO]
- cognition [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [ISO]
- learning [IMP]
- locomotory behavior [IGI, IMP]
- negative regulation of locomotion [ISO]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of long-term neuronal synaptic plasticity [ISO]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IBA, ISO]
- protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of synaptic transmission, glutamatergic [IBA]
- regulation of transcription, DNA-templated [ISO]
- synaptic transmission [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID