BAIT
TNIK
1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik
TRAF2 and NCK interacting kinase
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of JNKK activity [ISO]
- cytoskeleton organization [ISO]
- intracellular signal transduction [IBA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of dendrite morphogenesis [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NLGN2
NL2, RP23-422L16.24
neuroligin 2
GO Process (23)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- gephyrin clustering [IDA]
- jump response [ISO]
- locomotory exploration behavior [IMP]
- neuromuscular process controlling balance [IMP]
- neuron cell-cell adhesion [IBA, ISO]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- positive regulation of synapse assembly [ISO]
- positive regulation of synaptic transmission, GABAergic [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density protein 95 clustering [IDA]
- postsynaptic membrane assembly [IDA]
- presynaptic membrane assembly [IDA, IMP, ISO]
- protein localization to synapse [IDA]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- regulation of respiratory gaseous exchange by neurological system process [IGI]
- regulation of synaptic transmission [IGI]
- sensory perception of pain [IMP]
- social behavior [ISO]
- synapse assembly [ISO]
- synapse organization [ISO]
- terminal button organization [ISO]
- thigmotaxis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- Adult postsynaptic density (PSD)
Curated By
- BioGRID