BAIT
TNIK
1500031A17Rik, 4831440I19Rik, AI451411, C530008O15Rik, C630040K21Rik
TRAF2 and NCK interacting kinase
GO Process (9)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of JNKK activity [ISO]
- cytoskeleton organization [ISO]
- intracellular signal transduction [IBA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IBA, ISO]
- regulation of dendrite morphogenesis [ISO]
- response to stress [IBA]
- signal transduction by phosphorylation [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
KDM1A
1810043O07Rik, AA408884, Aof2, D4Ertd478e, Kdm1, Lsd1, mKIAA0601, RP23-426N4.2
lysine (K)-specific demethylase 1A
GO Process (31)
GO Function (18)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [IMP]
- chromatin organization involved in regulation of transcription [IC]
- granulocyte differentiation [IMP]
- guanine metabolic process [ISO]
- histone H3-K4 demethylation [ISO]
- histone H3-K9 demethylation [IMP, ISO]
- in utero embryonic development [IMP]
- muscle cell development [IMP]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [ISO]
- negative regulation of histone H3-K4 methylation [IMP]
- negative regulation of histone H3-K9 methylation [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- oxidation-reduction process [ISO]
- pituitary gland development [IMP]
- positive regulation of cell size [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of erythrocyte differentiation [IMP]
- positive regulation of hormone biosynthetic process [IMP]
- positive regulation of megakaryocyte differentiation [IMP]
- positive regulation of neural precursor cell proliferation [IMP]
- positive regulation of neuron projection development [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of stem cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- protein demethylation [ISO]
- regulation of primitive erythrocyte differentiation [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
- MRF binding [IPI, ISO]
- RNA polymerase II transcription factor binding [IPI]
- androgen receptor binding [ISO]
- chromatin binding [ISO]
- demethylase activity [ISO]
- enzyme binding [IPI, ISO]
- flavin adenine dinucleotide binding [ISO]
- histone demethylase activity [ISO]
- histone demethylase activity (H3-K4 specific) [ISO]
- histone demethylase activity (H3-K9 specific) [ISO]
- histone demethylase activity (H3-dimethyl-K4 specific) [ISO]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- oxidoreductase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- e14
Curated By
- BioGRID