BAIT
TSC1
RP23-362N19.3
tuberous sclerosis 1
GO Process (33)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [IMP]
- cell projection organization [IMP]
- cell-matrix adhesion [ISO]
- cerebral cortex development [IMP]
- embryo development [IMP]
- glucose import [IMP]
- hippocampus development [IMP]
- kidney development [IMP]
- myelination [IMP]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IGI, IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [IMP]
- neural tube closure [IMP]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [IGI, IMP]
- protein heterooligomerization [ISO]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IBA, ISO]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [IGI]
- regulation of stress fiber assembly [ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
EPHA4
2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb
Eph receptor A4
GO Process (20)
GO Function (8)
GO Component (19)
Gene Ontology Biological Process
- adult walking behavior [IMP]
- axon guidance [IGI, IMP]
- corticospinal tract morphogenesis [IMP]
- ephrin receptor signaling pathway [IMP]
- fasciculation of motor neuron axon [IMP]
- fasciculation of sensory neuron axon [IMP]
- glial cell migration [ISO]
- motor neuron axon guidance [IMP]
- negative regulation of axon regeneration [IMP, ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of Rho guanyl-nucleotide exchange factor activity [ISO]
- positive regulation of dendrite morphogenesis [ISO]
- protein autophosphorylation [ISO]
- regulation of Rac GTPase activity [IDA]
- regulation of Rap GTPase activity [IMP]
- regulation of Rho GTPase activity [ISO]
- regulation of astrocyte differentiation [IMP]
- regulation of axonogenesis [IMP]
- regulation of dendritic spine morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axon [IDA]
- axon terminus [ISO]
- axonal growth cone [ISO]
- cell body [ISO]
- cell projection [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [IDA, ISO]
- dendritic spine [ISO]
- early endosome membrane [IDA]
- endoplasmic reticulum [ISO]
- filopodium [ISO]
- integral component of plasma membrane [IDA, ISO]
- mitochondrial outer membrane [ISO]
- neuromuscular junction [ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- postsynaptic density [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- e14
Curated By
- BioGRID