BAIT
TSC1
RP23-362N19.3
tuberous sclerosis 1
GO Process (33)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- activation of Rho GTPase activity [ISO]
- cardiac muscle cell differentiation [IMP]
- cell projection organization [IMP]
- cell-matrix adhesion [ISO]
- cerebral cortex development [IMP]
- embryo development [IMP]
- glucose import [IMP]
- hippocampus development [IMP]
- kidney development [IMP]
- myelination [IMP]
- negative regulation of TOR signaling [IBA, ISO]
- negative regulation of cell proliferation [IMP, ISO]
- negative regulation of cell size [IGI, IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [ISO]
- nervous system development [IMP]
- neural tube closure [IMP]
- positive regulation of focal adhesion assembly [ISO]
- potassium ion transport [IGI, IMP]
- protein heterooligomerization [ISO]
- protein stabilization [ISO]
- rRNA export from nucleus [ISO]
- regulation of Ras GTPase activity [IBA]
- regulation of actin cytoskeleton organization [IBA, ISO]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of phosphoprotein phosphatase activity [ISO]
- regulation of protein kinase activity [IGI]
- regulation of stress fiber assembly [ISO]
- regulation of translation [ISO]
- response to insulin [ISO]
- synapse organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TRIM28
AA408787, KAP-1, KRIP-1, MommeD9, Tif1b, Tif1beta
tripartite motif-containing 28
GO Process (21)
GO Function (13)
GO Component (6)
Gene Ontology Biological Process
- DNA methylation involved in embryo development [IMP]
- DNA repair [ISO]
- convergent extension involved in axis elongation [IMP]
- embryo implantation [IMP]
- embryonic placenta morphogenesis [IMP]
- epithelial to mesenchymal transition [IDA]
- in utero embryonic development [IMP]
- innate immune response [ISO]
- negative regulation of DNA demethylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, IMP, ISO]
- negative regulation of viral release from host cell [ISO]
- positive regulation of DNA repair [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein autophosphorylation [IDA]
- protein oligomerization [ISO]
- protein phosphorylation [IDA]
- protein sumoylation [ISO]
- protein ubiquitination [ISO]
- regulation of genetic imprinting [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- Krueppel-associated box domain binding [ISO]
- chromo shadow domain binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- zinc ion binding [ISO]
- DNA binding [IDA, ISO]
- Krueppel-associated box domain binding [ISO]
- chromo shadow domain binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription corepressor activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.
The postsynaptic density (PSD) contains a collection of scaffold proteins used for assembling synaptic signaling complexes. However, it is not known how the core-scaffold machinery associates in protein-interaction networks or how proteins encoded by genes involved in complex brain disorders are distributed through spatiotemporal protein complexes. Here using immunopurification, proteomics and bioinformatics, we isolated 2,876 proteins across 41 in vivo ... [more]
Nat. Neurosci. Aug. 01, 2017; 20(8);1150-1161 [Pubmed: 28671696]
Throughput
- High Throughput
Additional Notes
- e14
Curated By
- BioGRID