LPAR1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO]
- activation of MAPK activity [IDA]
- bleb assembly [IGI]
- negative regulation of neuron projection development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of dendritic spine development [ISO]
- positive regulation of smooth muscle cell chemotaxis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CD14
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [ISO]
- cellular response to lipoteichoic acid [ISO]
- inflammatory response [ISO]
- positive regulation of cytokine secretion [ISO]
- positive regulation of endocytosis [IMP]
- positive regulation of tumor necrosis factor production [ISO]
- response to molecule of bacterial origin [IDA]
- response to tumor necrosis factor [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury.
Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown. Here we identify two enzymes that regulate the balance of LPA1 ubiquitination and deubiquitination. Ubiquitin E3 ligase Nedd4L targets LPA1 for its site specific ubiquitination and degradation in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID