DVL3
Gene Ontology Biological Process
- Wnt signaling pathway [ISO]
- Wnt signaling pathway, planar cell polarity pathway [IGI, ISO, TAS]
- canonical Wnt signaling pathway [ISO, TAS]
- cochlea morphogenesis [IGI]
- heart morphogenesis [IGI]
- non-canonical Wnt signaling pathway [ISO]
- non-canonical Wnt signaling pathway via JNK cascade [IDA]
- outflow tract septum morphogenesis [IMP]
- planar cell polarity pathway involved in neural tube closure [IGI]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
PDZRN3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling.
Development and stabilization of a vascular plexus requires the coordination of multiple signalling processes. Wnt planar cell polarity (PCP) signalling is critical in vertebrates for diverse morphogenesis events, which coordinate cell orientation within a tissue-specific plane. However, its functional role in vascular morphogenesis is not well understood. Here we identify PDZRN3, an ubiquitin ligase, and report that Pdzrn3 deficiency impairs ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID