Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

Lim SK, Lu SY, Kang SA, Tan HJ, Li Z, Adrian Wee ZN, Guan JS, Reddy Chichili VP, Sivaraman J, Putti T, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, Hong W, Lim YP

Cross-talk between the Hippo and Wnt pathways has been implicated recently in breast cancer development, but key intersections have yet to be fully defined. Here we report that WBP2, a transcription coactivator that binds the Hippo pathway transcription factor YAP/TAZ, contributes to Wnt signaling and breast cancer pathogenesis. Clinically, overexpression of WBP2 in breast cancer specimens correlated with malignant progression ... [more]

Cancer Res. Nov. 01, 2016; 76(21);6278-6289 [Pubmed: 27578003]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

WBP2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter sequence-specific DNA binding [IMP]RNA polymerase II transcription coactivator activity [IMP]chromatin DNA binding [IMP]protein binding [IPI]

Gene Ontology Cellular Component

TOM1L2

Gene Ontology Biological Process

Gene Ontology Molecular Function

clathrin binding [IDA]protein binding [IPI]protein kinase binding [IPI]

Gene Ontology Cellular Component

Two-hybrid

Publication

Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2.

Throughput

Curated By

RNA polymerase II core promoter sequence-specific DNA binding [IMP]
RNA polymerase II transcription coactivator activity [IMP]
chromatin DNA binding [IMP]
protein binding [IPI]

clathrin binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]