BAIT

FANCD2

FA-D2, FA4, FACD, FAD, FAD2, FANCD
Fanconi anemia, complementation group D2
Fanconi Anemia Project
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

PARP2

ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
poly (ADP-ribose) polymerase 2
GO Process (1)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

Ward TA, McHugh PJ, Durant ST

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human cancer cell-lines identify colorectal and gastric cell-lines with microsatellite instability (MSI) as enriched for cellular sensitivity ... [more]

PLoS ONE Jun. 20, 2017; 12(6);e0179278 [Pubmed: 28628639]

Throughput

  • Low Throughput

Additional Notes

  • Cells with bait knockdown using shRNA, and inhibition of hit with olaparib had lower survival than control

Curated By

  • BioGRID