PREY

PARP2

ADPRT2, ADPRTL2, ADPRTL3, ARTD2, PARP-2, pADPRT-2
poly (ADP-ribose) polymerase 2
GO Process (1)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.

Ward TA, McHugh PJ, Durant ST

Flap endonuclease 1 (FEN1) is a structure selective endonuclease required for proficient DNA replication and the repair of DNA damage. Cellularly active inhibitors of this enzyme have previously been shown to induce a DNA damage response and, ultimately, cell death. High-throughput screens of human cancer cell-lines identify colorectal and gastric cell-lines with microsatellite instability (MSI) as enriched for cellular sensitivity ... [more]

PLoS ONE Jun. 20, 2017; 12(6);e0179278 [Pubmed: 28628639]

Throughput

  • Low Throughput

Additional Notes

  • Cells with bait knockdown using shRNA, and inhibition of hit with olaparib had lower survival than control

Curated By

  • BioGRID