BAIT
NFKB1
NF-KB1, NF-kappaB, NF-kappaB1, p105, p50, p50/p105
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
GO Process (25)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IBA]
- NIK/NF-kappaB signaling [IBA]
- cellular response to interleukin-6 [ISO]
- cellular response to lipopolysaccharide [ISO]
- cellular response to nicotine [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to stress [IBA]
- innate immune response [IBA]
- lymph node development [TAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of calcidiol 1-monooxygenase activity [ISO]
- negative regulation of cytokine production [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-12 biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of hyaluronan biosynthetic process [ISO]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- response to cytokine [IBA]
- response to muscle stretch [IDA]
- response to oxidative stress [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- heat shock protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- regulatory region DNA binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IBA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- heat shock protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- regulatory region DNA binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
RELA
p65
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
GO Process (41)
GO Function (25)
GO Component (8)
Gene Ontology Biological Process
- NIK/NF-kappaB signaling [IBA]
- cellular response to hydrogen peroxide [ISO]
- cellular response to interleukin-1 [ISO]
- cellular response to interleukin-6 [ISO]
- cellular response to nicotine [ISO]
- cellular response to peptide hormone stimulus [ISO]
- cellular response to stress [IBA]
- cellular response to tumor necrosis factor [ISO]
- cytokine-mediated signaling pathway [ISO]
- defense response [IMP]
- hair follicle development [IMP]
- inflammatory response [ISO]
- innate immune response [IBA]
- liver development [IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IDA, ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- organ morphogenesis [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of Schwann cell differentiation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of interleukin-12 biosynthetic process [IDA]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IBA, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO, TAS]
- regulation of inflammatory response [IDA]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to UV-B [ISO]
- response to bacterium [IDA]
- response to cytokine [IBA]
- response to interleukin-1 [ISO]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- response to organic substance [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [IDA, ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA, ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- activating transcription factor binding [ISO]
- ankyrin repeat binding [IPI]
- chromatin binding [IDA, ISO]
- enzyme binding [IPI]
- identical protein binding [ISO]
- phosphate ion binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI, ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells.
Hematopoietic stem/progenitor cells (HSPCs) function to give rise to mature blood cells. Effective DNA damage response (DDR) and maintenance of genomic stability are crucial for normal functioning of HSPCs. Mammalian target of rapamycin (mTOR) integrates signals from nutrients and growth factors to control protein synthesis, cell growth, survival and metabolism, and has been shown to regulate DDR in yeast and ... [more]
Leukemia Oct. 01, 2013; 27(10);2040-2046 [Pubmed: 23538752]
Throughput
- Low Throughput
Curated By
- BioGRID