HDAC9
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- cellular response to insulin stimulus [ISO]
- chromatin modification [TAS]
- heart development [IGI]
- histone H3 deacetylation [ISO]
- histone H4 deacetylation [ISO]
- histone deacetylation [ISO, TAS]
- inflammatory response [TAS]
- negative regulation of striated muscle tissue development [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA, ISO, TAS]
- nervous system development [TAS]
- peptidyl-lysine deacetylation [ISO]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- regulation of skeletal muscle fiber development [IGI]
- regulation of striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BTG2
Gene Ontology Biological Process
- anterior/posterior pattern specification [ISO]
- associative learning [ISO]
- cellular response to DNA damage stimulus [ISO]
- central nervous system neuron development [ISO]
- dentate gyrus development [ISO]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of neural precursor cell proliferation [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of translation [ISO, ISS]
- neuron differentiation [IDA, IEP]
- neuron projection development [ISO]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISO]
- protein methylation [ISO]
- response to electrical stimulus [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organic substance [IEP]
- response to organonitrogen compound [IEP]
- response to peptide hormone [IEP]
- skeletal muscle cell differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
HDAC1, HDAC4, and HDAC9 Bind to PC3/Tis21/Btg2 and Are Required for Its Inhibition of Cell Cycle Progression and Cyclin D1 Expression.
PC3/Tis21 is a transcriptional cofactor that inhibits proliferation in several cell types, including neural progenitors. Here, we report that PC3/Tis21 associates with HDAC1, HDAC4, and HDAC9 in vivo, in fibroblast cells. Furthermore, when HDAC1, HDAC4, or HDAC9 are silenced in fibroblasts or in a line of cerebellar progenitor cells, the ability of PC3/Tis21 to inhibit proliferation is significantly reduced. Overexpression ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID