BAIT
MTNR1A
MEL-1A-R, MT1
melatonin receptor 1A
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STXBP1
AI317162, AI326233, MMS10-G, Ms10g, Munc-18a, Munc18-1, N-sec1, Rb-sec1, Sxtbp1, Unc18-1, Unc18h, nsec1, RP23-17P12.13-002
syntaxin binding protein 1
GO Process (16)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- axon target recognition [IMP]
- exocytosis [IMP]
- long term synaptic depression [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of synaptic transmission, GABAergic [IDA]
- neuromuscular synaptic transmission [IMP]
- neurotransmitter secretion [IMP]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [IDA]
- positive regulation of exocytosis [ISO]
- protein localization to plasma membrane [ISO]
- protein stabilization [ISO]
- regulation of synaptic vesicle priming [ISO]
- synaptic vesicle maturation [IMP]
- vesicle docking involved in exocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]
J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]
Throughput
- Low Throughput
Curated By
- BioGRID