BAIT

BEM1

SRO1, phosphatidylinositol-3-phosphate-binding protein BEM1, L000000167, YBR200W
Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
Saccharomyces cerevisiae (S288c)
PREY

RDI1

L000002743, YDL135C
Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress
GO Process (3)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Role of competition between polarity sites in establishing a unique front.

Wu CF, Chiou JG, Minakova M, Woods B, Tsygankov D, Zyla TR, Savage NS, Elston TC, Lew DJ

Polarity establishment in many cells is thought to occur via positive feedback that reinforces even tiny asymmetries in polarity protein distribution. Cdc42 and related GTPases are activated and accumulate in a patch of the cortex that defines the front of the cell. Positive feedback enables spontaneous polarization triggered by stochastic fluctuations, but as such fluctuations can occur at multiple locations, ... [more]

Elife Nov. 02, 2015; 4(); [Pubmed: 26523396]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: budding (APO:0000024)

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RDI1 BEM1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1893BioGRID
363288
BEM1 RDI1
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-0.1893BioGRID
359108

Curated By

  • BioGRID