BAIT
YNG2
EAF4, NBN1, histone acetyltransferase YNG2, L000004452, YHR090C
Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5
GO Process (3)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
AIR2
YDL175C
RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome
GO Process (8)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- ncRNA polyadenylation [IDA]
- nuclear mRNA surveillance of mRNA 3'-end processing [IGI]
- nuclear polyadenylation-dependent CUT catabolic process [IGI]
- nuclear polyadenylation-dependent rRNA catabolic process [IGI]
- nuclear polyadenylation-dependent snRNA catabolic process [IGI]
- nuclear polyadenylation-dependent snoRNA catabolic process [IGI]
- nuclear polyadenylation-dependent tRNA catabolic process [IDA]
- tRNA modification [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome.
Recognition of histone marks by reader modules is thought to be at the heart of epigenetic mechanisms. These protein domains are considered to function by targeting regulators to chromosomal loci carrying specific histone modifications. This is important for proper gene regulation as well as propagation of epigenetic information. The NuA4 acetyltransferase complex contains two of these reader modules, an H3K4me3-specific ... [more]
Mol. Cell. Biol. Nov. 15, 2016; 36(22);2768-2781 [Pubmed: 27550811]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- E-MAP, significance >2 or <-2.5
- yng2 - W247A
Curated By
- BioGRID