AAH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
WHI5
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
A systematic genetic screen for genes involved in sensing inorganic phosphate availability in Saccharomyces cerevisiae.
Saccharomyces cerevisiae responds to changes in extracellular inorganic phosphate (Pi) availability by regulating the activity of the phosphate-responsive (PHO) signaling pathway, enabling cells to maintain intracellular levels of the essential nutrient Pi. Pi-limitation induces upregulation of inositol heptakisphosphate (IP7) synthesized by the inositol hexakisphosphate kinase Vip1, triggering inhibition of the Pho80/Pho85 cyclin-cyclin dependent kinase (CDK) complex by the CDK inhibitor ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: protein activity (APO:0000022)
Additional Notes
- double mutants show a reduction in activation of the PHO pathway in aah1 mutant cells in high Pi conditions
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
WHI5 AAH1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1344 | BioGRID | 2183413 |
Curated By
- BioGRID