MTNR1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DMD
Gene Ontology Biological Process
- cardiac muscle cell action potential [IMP]
- cardiac muscle contraction [ISO]
- cellular protein complex assembly [IMP]
- cellular protein localization [IMP, ISO]
- establishment of blood-nerve barrier [IMP]
- establishment of glial blood-brain barrier [IMP]
- muscle cell cellular homeostasis [IMP]
- muscle fiber development [IGI]
- muscle organ development [IMP]
- myotube cell development [IMP]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of peptidyl-cysteine S-nitrosylation [IMP]
- negative regulation of peptidyl-serine phosphorylation [IMP]
- neurotransmitter receptor metabolic process [IMP]
- nucleus localization [IMP]
- olfactory nerve structural organization [IMP]
- peptide biosynthetic process [ISO]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transmembrane transporter activity [IMP]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IMP]
- regulation of cellular response to growth factor stimulus [ISO]
- regulation of gene expression [IMP]
- regulation of heart rate [IMP, ISO]
- regulation of membrane potential [IMP]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IMP]
- regulation of ryanodine-sensitive calcium-release channel activity [IMP]
- regulation of skeletal muscle contraction [IMP]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IMP]
- regulation of transcription, DNA-templated [IMP]
- regulation of voltage-gated calcium channel activity [IMP]
- response to muscle stretch [IMP]
- skeletal muscle tissue development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Z disc [IDA]
- cell [IMP]
- cell surface [ISO]
- cell-substrate junction [IDA]
- costamere [ISO]
- dystrophin-associated glycoprotein complex [IDA, ISO]
- filopodium [ISO]
- filopodium membrane [ISO]
- intracellular [IMP]
- membrane raft [IDA]
- neuron projection terminus [IDA]
- nucleus [ISO]
- plasma membrane [IDA]
- protein complex [ISO]
- sarcolemma [IDA, ISO]
- synapse [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]
Throughput
- High Throughput
Curated By
- BioGRID