BAIT
MTNR1B
FGQTL2, MEL-1B-R, MT2
melatonin receptor 1B
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRKCZ
AI098070, C80388, Pkcz, R74924, aPKCzeta, nPKC-zeta, zetaPKC, RP23-298E4.6
protein kinase C, zeta
GO Process (43)
GO Function (10)
GO Component (21)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of phospholipase D activity [ISO]
- activation of protein kinase B activity [ISO]
- cell migration [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [ISO]
- establishment of cell polarity [ISO]
- insulin receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- microtubule cytoskeleton organization [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T-helper 2 cell cytokine production [IMP]
- positive regulation of T-helper 2 cell differentiation [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-13 secretion [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of interleukin-5 secretion [IMP]
- positive regulation of protein transport [ISO]
- positive regulation of synaptic transmission [ISO]
- protein heterooligomerization [ISO]
- protein kinase C signaling [ISO]
- protein localization to plasma membrane [IMP]
- protein phosphorylation [IDA, ISO]
- signal transduction [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [IDA]
- apical plasma membrane [IDA]
- axon hillock [IDA]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell junction [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [ISO]
- microtubule organizing center [IGI]
- myelin sheath abaxonal region [IDA]
- nuclear envelope [IDA]
- nuclear matrix [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [IDA]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]
J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MTNR1B PRKCZ | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | High | - | BioGRID | - |
Curated By
- BioGRID