BAIT
MTNR1B
FGQTL2, MEL-1B-R, MT2
melatonin receptor 1B
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HSPH1
105kDa, AI790491, Hsp105, Hsp110, hsp-E7I
heat shock 105kDa/110kDa protein 1
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- chaperone mediated protein folding requiring cofactor [IDA]
- establishment of protein localization to mitochondrion [IMP]
- intrinsic apoptotic signaling pathway in response to hydrogen peroxide [IMP]
- negative regulation of apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [TAS]
- positive regulation of MHC class I biosynthetic process [TAS]
- positive regulation of NK T cell activation [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of microtubule cytoskeleton organization [NAS]
- regulation of p38MAPK cascade [IGI]
- response to unfolded protein [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]
J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MTNR1B HSPH1 | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | High | - | BioGRID | - |
Curated By
- BioGRID