BAIT

MTNR1B

FGQTL2, MEL-1B-R, MT2
melatonin receptor 1B
Homo sapiens
PREY

GNAI1

Gi
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R

In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]

J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]

Throughput

  • High Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MTNR1B GNAI1
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Low-BioGRID
-

Curated By

  • BioGRID