BAIT
MTNR1A
MEL-1A-R, MT1
melatonin receptor 1A
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PRELID1
PRELI, PX19, SBBI12, CGI-106
PRELI domain containing 1
GO Process (13)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- immune response [TAS]
- multicellular organismal development [TAS]
- negative regulation of apoptotic process [IDA, IMP]
- negative regulation of mitochondrial membrane potential [IDA]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- phospholipid transport [IMP]
- positive regulation of T cell apoptotic process [IDA]
- positive regulation of cellular respiration [IDA]
- positive regulation of endopeptidase activity [IDA]
- positive regulation of phospholipid transport [IDA]
- regulation of T cell differentiation [IDA]
- regulation of membrane lipid distribution [IDA]
- regulation of mitochondrial membrane potential [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]
J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]
Throughput
- High Throughput
Curated By
- BioGRID