BAIT

MTNR1B

FGQTL2, MEL-1B-R, MT2

melatonin receptor 1B

GO Process (4)

GO Function (2)

GO Component (2)

Gene Ontology Biological Process

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [TAS]

glucose homeostasis [IMP]

regulation of insulin secretion [IMP]

synaptic transmission [TAS]

Gene Ontology Molecular Function

G-protein coupled receptor activity [TAS]
protein binding [IPI]

Gene Ontology Cellular Component

integral component of plasma membrane [TAS]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

THRA

AR7, CHNG6, EAR7, ERB-T-1, ERBA, ERBA1, NR1A1, THRA1, THRA2, c-ERBA-1

thyroid hormone receptor, alpha

GO Process (8)

GO Function (8)

GO Component (3)

Gene Ontology Biological Process

gene expression [TAS]

hormone-mediated signaling pathway [IDA]

negative regulation of DNA-templated transcription, initiation [IDA]

negative regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]

negative regulation of transcription, DNA-templated [IDA]

regulation of transcription from RNA polymerase II promoter [IDA]

transcription from RNA polymerase II promoter [IDA]

transcription initiation from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

TBP-class protein binding [IDA]
protein binding [IPI]
protein domain specific binding [IPI]
sequence-specific DNA binding transcription factor activity [IDA]
thyroid hormone binding [IDA, IPI]
thyroid hormone receptor activity [IDA]
transcription factor binding [IPI]
transcription regulatory region DNA binding [IDA]

Gene Ontology Cellular Component

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R

In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]

J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]

Throughput

High Throughput

Curated By

BioGRID