BAIT

MTNR1B

FGQTL2, MEL-1B-R, MT2
melatonin receptor 1B
Homo sapiens
PREY

SLC3A2

4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
solute carrier family 3 (amino acid transporter heavy chain), member 2
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R

In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]

J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]

Throughput

  • High Throughput

Curated By

  • BioGRID