Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R

In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]

J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

MTNR1B

Gene Ontology Biological Process

Gene Ontology Molecular Function

G-protein coupled receptor activity [TAS]protein binding [IPI]

Gene Ontology Cellular Component

DST

Gene Ontology Biological Process

Gene Ontology Molecular Function

integrin binding [IPI]microtubule plus-end binding [IDA]protein C-terminus binding [IPI]protein binding [IPI]protein homodimerization activity [IDA]

Gene Ontology Cellular Component

Two-hybrid

Publication

Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.

Throughput

Curated By

G-protein coupled receptor activity [TAS]
protein binding [IPI]

integrin binding [IPI]
microtubule plus-end binding [IDA]
protein C-terminus binding [IPI]
protein binding [IPI]
protein homodimerization activity [IDA]