BAIT
MTNR1B
FGQTL2, MEL-1B-R, MT2
melatonin receptor 1B
GO Process (4)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC30A1
ZNT1, ZRC1
solute carrier family 30 (zinc transporter), member 1
GO Process (8)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- cadmium ion transmembrane transport [ISS]
- cellular calcium ion homeostasis [ISS]
- cellular zinc ion homeostasis [ISS]
- negative regulation of calcium ion import [ISS]
- negative regulation of neurotransmitter secretion [ISS]
- negative regulation of zinc ion transmembrane import [ISS]
- transmembrane transport [TAS]
- zinc ion transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
In mammals, the hormone melatonin is mainly produced by the pineal gland with nocturnal peak levels. Its peripheral and central actions rely either on its intrinsic antioxidant properties or on binding to melatonin MT1 and MT2 receptors, belonging to the G protein-coupled receptor (GPCR) super-family. Melatonin has been reported to be involved in many functions of the central nervous system ... [more]
J. Pineal Res. Jan. 01, 2016; 60(1);95-108 [Pubmed: 26514267]
Throughput
- High Throughput
Curated By
- BioGRID