BAIT
ERG
erg-3, p55
v-ets avian erythroblastosis virus E26 oncogene homolog
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBR4
RBAF600, ZUBR1, p600, RP5-1126H10.1
ubiquitin protein ligase E3 component n-recognin 4
GO Process (1)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.
Ets related gene (ERG) is a transcription factor that is overexpressed in 40% of prostate tumors due to a gene fusion between ERG and TMPRSS2. Because ERG functions as a driver of prostate carcinogenesis, understanding the mechanisms that influence its turnover may provide new molecular handles to target the protein. Previously, we found that ERG undergoes ubiquitination and then is ... [more]
Oncotarget Oct. 04, 2016; 7(40);64921-64931 [Pubmed: 27626314]
Throughput
- High Throughput
Curated By
- BioGRID