BAIT
FKBP1B
FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase
FK506 binding protein 1B, 12.6 kDa
GO Process (18)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- 'de novo' protein folding [TAS]
- calcium ion transmembrane transport [TAS]
- calcium-mediated signaling using intracellular calcium source [TAS]
- cell communication by electrical coupling involved in cardiac conduction [TAS]
- chaperone-mediated protein folding [IBA]
- cytosolic calcium ion homeostasis [IDA, IGI]
- negative regulation of heart rate [ISS]
- negative regulation of protein phosphatase type 2B activity [IDA]
- negative regulation of release of sequestered calcium ion into cytosol [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- positive regulation of sequestering of calcium ion [IDA]
- protein maturation by protein folding [TAS]
- protein peptidyl-prolyl isomerization [IDA]
- protein refolding [TAS]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IBA, ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of ryanodine-sensitive calcium-release channel activity [IDA, IMP]
- response to redox state [IDA]
Gene Ontology Molecular Function
Homo sapiens
PREY
RYR3
RYR-3
ryanodine receptor 3
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- calcium ion transmembrane transport [ISS]
- calcium ion transport [IMP]
- cellular response to ATP [ISS]
- cellular response to caffeine [ISS]
- cellular response to calcium ion [ISS]
- cellular response to magnesium ion [ISS]
- ion transmembrane transport [TAS]
- protein homotetramerization [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different.
We compared the interaction of the FK506-binding protein (FKBP) with the type 3 ryanodine receptor (RyR3) and with the type 1 and type 3 inositol 1,4,5-trisphosphate receptor (IP(3)R1 and IP(3)R3), using a quantitative GST-FKBP12 and GST-FKBP12.6 affinity assay. We first characterized and mapped the interaction of the FKBPs with the RyR3. GST-FKBP12 as well as GST-FKBP12.6 were able to bind ... [more]
J. Biol. Chem. Dec. 14, 2001; 276(50);47715-24 [Pubmed: 11598113]
Throughput
- Low Throughput
Curated By
- BioGRID