BAIT

NDJ1

TAM1, L000003266, L000003597, YOL104C
Meiosis-specific telomere protein; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement
Saccharomyces cerevisiae (S288c)
PREY

SPO11

L000002002, YHL022C
Meiosis-specific protein that initiates meiotic recombination; initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Ndj1, a telomere-associated protein, regulates centrosome separation in budding yeast meiosis.

Li P, Shao Y, Jin H, Yu HG

Yeast centrosomes (called spindle pole bodies [SPBs]) remain cohesive for hours during meiotic G2 when recombination takes place. In contrast, SPBs separate within minutes after duplication in vegetative cells. We report here that Ndj1, a previously known meiosis-specific telomere-associated protein, is required for protecting SPB cohesion. Ndj1 localizes to the SPB but dissociates from it ∼16 min before SPB separation. ... [more]

J. Cell Biol. Apr. 27, 2015; 209(2);247-59 [Pubmed: 25897084]

Throughput

  • Low Throughput

Ontology Terms

  • chromosome segregation (APO:0000208)

Additional Notes

  • separation of spindle pole bodies

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
NDJ1 SPO11
Phenotypic Suppression
Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
2334530

Curated By

  • BioGRID