An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities.

Fotia AB, Cook DI, Kumar S

Nedd4 and Nedd4-2 are closely related HECT-type ubiquitin-protein ligases (E3) implicated in the regulation of a number of proteins and pathways. Given the close homology between these E3 enzymes it would be predicted that a conserved ubiquitin-conjugating enzyme (E2) specificity exists between the two proteins. However, E2 specificities for Nedd4 and Nedd4-2 are not well established. In the present studies ... [more]

Int. J. Biochem. Cell Biol. Mar. 01, 2006; 38(3);472-9 [Pubmed: 16337426]

Throughput

Low Throughput

Additional Notes

E2s: UBE2D2, UBE2D1, UBE2L3

Curated By

BioGRID

Interaction Summary

NEDD4

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphoserine binding [IDA]phosphothreonine binding [IDA]proline-rich region binding [IPI]protein C-terminus binding [ISO]protein binding [IPI]sodium channel inhibitor activity [IDA]ubiquitin protein ligase activity [IDA]ubiquitin-protein transferase activity [ISO]

Gene Ontology Cellular Component

N4BP1