BAIT
RPD3
MOF6, REC3, SDI2, SDS6, histone deacetylase RPD3, L000001696, L000001603, YNL330C
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p
GO Process (19)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- chromatin organization involved in regulation of transcription [IMP]
- histone H3 deacetylation [IMP]
- histone H4 deacetylation [IMP]
- negative regulation of chromatin silencing at rDNA [IMP]
- negative regulation of chromatin silencing at silent mating-type cassette [IMP]
- negative regulation of chromatin silencing at telomere [IDA, IMP]
- negative regulation of reciprocal meiotic recombination [IMP]
- negative regulation of transcription during meiosis [IMP]
- negative regulation of transcription from RNA polymerase I promoter [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP, IPI]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- protein localization to nucleolar rDNA repeats [IMP]
- regulation of DNA-dependent DNA replication initiation [IGI, IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI, IPI]
- regulation of transcription involved in G2/M transition of mitotic cell cycle [IGI]
- replicative cell aging [IMP]
- transcription elongation from RNA polymerase II promoter [IGI]
- transfer RNA gene-mediated silencing [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
ARG82
ARGR3, IPK2, inositol polyphosphate multikinase, ARGRIII, L000002727, YDR173C
Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
GO Process (6)
GO Function (7)
GO Component (1)
Gene Ontology Biological Process
- inositol phosphate biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- phosphatidylinositol phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein stabilization [IMP]
- regulation of arginine metabolic process [IMP]
Gene Ontology Molecular Function- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
- inositol tetrakisphosphate 3-kinase activity [IDA]
- inositol tetrakisphosphate 6-kinase activity [IDA]
- inositol-1,3,4,5,6-pentakisphosphate kinase activity [IDA]
- inositol-1,4,5-trisphosphate 3-kinase activity [IMP]
- inositol-1,4,5-trisphosphate 6-kinase activity [IDA]
- phosphatidylinositol 3-kinase activity [IDA]
- protein binding, bridging [IMP, IPI]
Saccharomyces cerevisiae (S288c)
Negative Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
An emerging therapeutic strategy for cancer is to induce selective lethality in a tumor by exploiting interactions between its driving mutations and specific drug targets. Here we use a multi-species approach to develop a resource of synthetic lethal interactions relevant to cancer therapy. First, we screen in yeast ∼169,000 potential interactions among orthologs of human tumor suppressor genes (TSG) and ... [more]
Mol. Cell Aug. 04, 2016; 63(3);514-25 [Pubmed: 27453043]
Quantitative Score
- -3.49 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- phenotype: colony size (APO:0000063)
Additional Notes
- Untreated conditions. SGA was used to score genetic interactions based on the colony size of double versus single mutants. Genetic interactions were considered significant if they had an S score >= 2.0 for positive interactions (epistatic or suppressor interactions) and S score <= -2.5 for negative interactions (synthetic sick/lethal interactions).
Curated By
- BioGRID