GSK3
Gene Ontology Biological Process
Gene Ontology Molecular Function
PMP1
Gene Ontology Biological Process
- cellular chloride ion homeostasis [IMP]
- cellular response to salt stress [IMP]
- inactivation of MAPK activity [IDA]
- peptidyl-tyrosine dephosphorylation [IDA]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [IDA]
- positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
- protein dephosphorylation [IDA]
- regulation of cell morphogenesis [IMP]
- regulation of mitotic cytokinesis [IMP]
- regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [IMP]
Gene Ontology Molecular Function
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
The Target of Rapamycin (TOR) signalling network plays important roles in aging and disease. The AMP-activated protein kinase (AMPK) and the Gsk3 kinase inhibit TOR during stress. We performed genetic interaction screens using synthetic genetic arrays (SGA) with gsk3 and amk2 as query mutants, the latter encoding the regulatory subunit of AMPK. We identified 69 negative and 82 positive common ... [more]
Quantitative Score
- 0.227 [Confidence Score]
Throughput
- High Throughput
Ontology Terms
- colony size (APO:0000063)
Additional Notes
- SGA was used to quantitatively scoregenetic interactions based on fitness defects estimated from the colony size of double versus single mutants. Genetic interactions were considered significant if they had a score >= 0.15for positive interactions (epistatic or suppressor interactions)and S score <= -0.15for negative interactions (synthetic sick/lethal interactions).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GSK3 PMP1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 1.9887 | BioGRID | 788048 | |
| PMP1 GSK3 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 1.9887 | BioGRID | 761686 |
Curated By
- BioGRID