PREY
ATP5A1
ATP5A, ATP5AL2, ATPM, COXPD22, HEL-S-123m, MC5DN4, MOM2, OMR, ORM, hATP1
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
GO Process (9)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- ATP biosynthetic process [IC, NAS]
- ATP catabolic process [IDA]
- cellular metabolic process [TAS]
- embryo development [ISS]
- lipid metabolic process [ISS]
- mitochondrial ATP synthesis coupled proton transport [IC, TAS]
- negative regulation of endothelial cell proliferation [IMP]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.
The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone complex involved in the assembly of a number of critical protein complexes including snoRNPs, nuclear RNA polymerases and PIKK-containing complexes. Here we report on the use of multiple target affinity purification coupled to mass spectrometry to identify two additional complexes that interact with R2TP/PFDL: the TSC1-TSC2 complex and the U5 small ... [more]
Nat Commun May. 31, 2017; 8();15615 [Pubmed: 28561026]
Quantitative Score
- 534.0 [Mascot Score]
Throughput
- High Throughput
Additional Notes
- False discovery rate (FDR) cutoff was set to 0.1 for the soluble fraction and 0.2 for the chromatin fraction.Some additional known interactors in the soluble fraction with an FDR < 0.2 were included.
- Soluble
Curated By
- BioGRID