BAIT
APC
BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
adenomatous polyposis coli
GO Process (21)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IC, NAS]
- cell adhesion [NAS]
- cell cycle arrest [IDA]
- cell migration [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- mitotic cytokinesis [IMP]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of microtubule depolymerization [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of protein catabolic process [IC, IGI]
- positive regulation of pseudopodium assembly [IMP]
- protein complex assembly [IDA]
- regulation of attachment of spindle microtubules to kinetochore [IMP, NAS]
- regulation of microtubule-based process [IMP]
- tight junction assembly [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSNK1D
ASPS, CKIdelta, FASPS2, HCKID
casein kinase 1, delta
GO Process (14)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein phosphorylation [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
- spindle assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.
The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines. We find that the β-catenin inhibitory domain (CID) in APC represents the threshold for pathological levels of Wnt activation and tumor ... [more]
Cell Rep Oct. 17, 2017; 21(3);612-627 [Pubmed: 29045831]
Throughput
- High Throughput
Curated By
- BioGRID