BAIT
ERBB4
ALS19, HER4, p180erbB4
erb-b2 receptor tyrosine kinase 4
GO Process (34)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- cardiac muscle tissue regeneration [ISS]
- cell migration [IDA]
- cell proliferation [TAS]
- central nervous system morphogenesis [ISS]
- embryonic pattern specification [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- innate immune response [TAS]
- lactation [IMP]
- mammary gland alveolus development [ISS]
- mammary gland epithelial cell differentiation [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- nervous system development [ISS]
- neural crest cell migration [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- olfactory bulb interneuron differentiation [ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of STAT protein import into nucleus [IMP]
- positive regulation of cardiac muscle cell proliferation [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein phosphorylation [TAS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP]
- protein autophosphorylation [IDA]
- regulation of cell migration [ISS]
- signal transduction [IDA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ESR1
ER, ESR, ESRA, ESTRR, Era, NR3A1, RP1-130E4.1
estrogen receptor 1
GO Process (22)
GO Function (16)
GO Component (6)
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- chromatin remodeling [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- intracellular steroid hormone receptor signaling pathway [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipase C activity [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [NAS]
- response to estradiol [IDA]
- response to estrogen [IDA]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia.
Mounting evidence from clinical and basic research suggests that estrogen signaling may be altered in the brains of people with schizophrenia. Previously, we found that DNA sequence variation in the estrogen receptor (ER) alpha gene, lower ERalpha mRNA levels, and/or blunted ERalpha signaling is associated with schizophrenia. In this study, we asked whether the naturally occurring truncated ERalpha isoform, Delta7, ... [more]
J. Biol. Chem. Jul. 10, 2009; 284(28);18824-32 [Pubmed: 19439407]
Throughput
- Low Throughput
Curated By
- BioGRID