SIGLEC9
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPN11
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- atrioventricular canal development [IMP]
- axon guidance [TAS]
- blood coagulation [TAS]
- brain development [IMP]
- cytokine-mediated signaling pathway [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- face morphogenesis [IMP]
- fibroblast growth factor receptor signaling pathway [TAS]
- genitalia development [IMP]
- heart development [IMP]
- innate immune response [TAS]
- inner ear development [IMP]
- insulin receptor signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of glucose import in response to insulin stimulus [IDA]
- regulation of cell adhesion mediated by integrin [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs.
Siglec-7 (p75/AIRM1) is an inhibitory receptor on human natural killer cells (NK cells) and monocytes. The cytoplasmic domain of Siglec-7 contains two signaling motifs: a membrane-proximal immunoreceptor tyrosine-based inhibitory motif (ITIM) (Ile435-Gln-Tyr-Ala-Pro-Leu440) and a membrane-distal motif (Asn458-Glu-Tyr-Ser-Glu-Ile463). We report here that, upon pervanadate (PV) treatment, Siglec-7 recruited the protein tyrosine phosphatases Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase-1 (SHP-1) and SHP-2 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID