BAIT
EHBP1L1
G430002G23Rik
EH domain binding protein 1-like 1
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
PREY
RAB8B
RAB8B, member RAS oncogene family
GO Process (13)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Golgi vesicle fusion to target membrane [IBA]
- Rab protein signal transduction [IBA]
- adherens junction organization [ISS]
- antigen processing and presentation [IMP]
- cellular response to insulin stimulus [IBA]
- cilium assembly [IMP]
- protein import into peroxisome membrane [IDA]
- protein localization to plasma membrane [IBA]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
The highly conserved Rab guanosine triphosphatase (GTPase) Rab8 plays a role in exocytosis toward the polarized plasma membrane in eukaryotic cells. In murine Rab8-deficient small intestine cells, apical proteins are missorted into lysosomes. In this study, we identified a novel Rab8-interacting protein complex containing an EH domain-binding protein 1-like 1 (EHBP1L1), Bin1/amphiphysin II, and dynamin. Biochemical analyses showed that EHBP1L1 ... [more]
J. Cell Biol. Feb. 01, 2016; 212(3);297-306 [Pubmed: 26833786]
Throughput
- Low Throughput
Curated By
- BioGRID