BAIT
EHBP1
AF424697, Flj21950, NACSIN, RP23-51G7.3
EH domain binding protein 1
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB10
RAB10, member RAS oncogene family
GO Process (21)
GO Function (4)
GO Component (14)
Gene Ontology Biological Process
- GTP catabolic process [IBA]
- Golgi to plasma membrane protein transport [ISS]
- Golgi to plasma membrane transport [ISS]
- Rab protein signal transduction [IBA]
- antigen processing and presentation [IMP]
- axonogenesis [ISS]
- basolateral protein localization [ISS]
- cellular response to insulin stimulus [IBA, ISS]
- endoplasmic reticulum tubular network organization [IMP]
- endosomal transport [IMP]
- establishment of neuroblast polarity [ISS]
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- establishment of protein localization to membrane [IMP]
- intracellular protein transport [IBA]
- membrane organization [TAS]
- polarized epithelial cell differentiation [ISS]
- protein localization to plasma membrane [IBA, ISS]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA]
- vesicle-mediated transport [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cytoplasmic vesicle membrane [TAS]
- endoplasmic reticulum membrane [IDA]
- endoplasmic reticulum tubular network [IDA]
- endosome [IDA]
- endosome membrane [IBA]
- exocyst [ISS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- insulin-responsive compartment [IDA]
- plasma membrane [IDA]
- primary cilium [IDA]
- recycling endosome [IDA]
- trans-Golgi network [ISS]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
The highly conserved Rab guanosine triphosphatase (GTPase) Rab8 plays a role in exocytosis toward the polarized plasma membrane in eukaryotic cells. In murine Rab8-deficient small intestine cells, apical proteins are missorted into lysosomes. In this study, we identified a novel Rab8-interacting protein complex containing an EH domain-binding protein 1-like 1 (EHBP1L1), Bin1/amphiphysin II, and dynamin. Biochemical analyses showed that EHBP1L1 ... [more]
J. Cell Biol. Feb. 01, 2016; 212(3);297-306 [Pubmed: 26833786]
Throughput
- Low Throughput
Curated By
- BioGRID